The labs of Tongye Shen and Rachel Patton McCord recently published an article in
Nucleic Acids Research. The article, Characterizing the 3D structure and dynamics of chromosomes and proteins in a common contact matrix framework, swapped principal component analysis methods designed for either proteins or chromosomes to analyze the other biopolymer type. They also combined computational analysis with Hi-C data to determine features of chromosome structure that can be used to differentiate cell types.
