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Brad Binder

Contact Info

FacultyBinderBrad Binder
Associate Professor, BCMB

Office: Hesler 343, (865-974-7994)
Lab: Hesler 106, (865-974-7997)
Email: bbinder@utk.edu

Lab Website: http://binderlab.utk.edu/

Ph.D. Neurosciences Training Program, University of Wisconsin-Madison

Research Statement

binder_research1My lab studies the mechanisms of signal transduction for the gas, ethylene. Ethylene is well-known as a hormone in plants where it regulates and influences many critical physiological and developmental processes such as fruit ripening. Ethylene is the underlying cause for the saying: one bad apple spoils the bunch. To understand ethylene signaling in plants, my lab primarily focuses on the model plant Arabidopsis thaliana. To pursue this research, we combine biochemistry, molecular biology, genetics, chemistry, modeling, and physiology. This multifaceted approach is allowing us to gain a better understanding of mechanisms of ethylene signaling and crosstalk with other pathways.

In contrast to plants, little is known about the role of ethylene in other organisms. Analysis of sequenced bacterial genomes has shown that many contain putative ethylene receptors. Therefore, we are studying the effects of ethylene on these species and the role of these receptors in bacteria. For more details about my research visit my Lab Page.

Selected Publications

[out of 70 total]

(underlined undergraduates, Graduate students)

Bakshi A, Piya S, Fernandez JC, Chervin C, Hewezi T, Binder BM. (2018) Ethylene Receptors Signal Via a Non-canonical Pathway to Regulate Abscisic Acid Responses. Plant Physiology 176: 910-929.

Lacey RL, Binder BM (2016) Ethylene Regulates the Physiology of the Cyanobacterium Synechocystis sp. PCC 6803 via an Ethylene Receptor. Plant Physiology 171: 2798-2809.

Merchante C, Brumos J, Yun J, Hu Q, Spencer KR, Enriquez P, Binder BM, Heber S, Stepanova AN, Alonso, JM. (2015) Gene-specific translation regulation mediated by the hormone-signaling molecule EIN2. Cell 163: 684-697.

McDaniel BK, Binder, BM. (2012) ETHYLENE RECEPTOR1 (ETR1) Is Sufficient and has the Predominant Role in Mediating Inhibition of Ethylene Responses by Silver in Arabidopsis thaliana. Journal of Biological Chemistry 287: 26094-26103.

Kim H, Helmbrecht E, Stalans MB, Schmitt CL, Patel N, Wen C-K, Wang W, Binder BM (2011) Ethylene Receptor ETHYLENE RECEPTOR1 Domain Requirements for Ethylene Responses in Arabidopsis Seedlings. Plant Physiology. 156: 417-429.

Rodriguez F, Esch J, Hall A, Binder BM, Schaller GE, Bleecker AB (1999) A Copper Cofactor for the ETR1 Receptor from Arabidopsis. Science 283: 996-998.

Pubmed List of Papers

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